The Netherlands
The Nijmegen Brain Imaging Genetics (BIG) project
Study website: www.cognomics.nl/big
Organization website: www.ru.nl
Study population size: 2500 participants
Study population: healthy population, aged 45 and older
Imaging modality 1: MRI – Brain
Key publications:
- Bralten J, Arias-Vásquez A, et al. Association of the Alzheimer’s gene SORL1 with hippocampal volume in young, healthy adults. American Journal of Psychiatry. 2011.
- Hoogman M, Rijpkema M, et al. Current self-reported symptoms of attention deficit/hyperactivity disorder are associated with total brain volume in healthy adults. PLoS One. 2012.
Generation R Study
Study website: www.generationr.nl
Organization website: www.erasmusmc.nl
Study population size: 10000 participants.
Study population: healthy children, from birth and on.
Imaging modality 1: ultrasound – Fetal, abdominal, thoracic
Imaging modality 2: MRI – brain, subgroup.
Key publications (see also: www.generationr.nl/researchers/phd-theses-and-publications.html):
- Jaddoe VW, van Duijn CM, et al. The Generation R Study: design and cohort update 2012. Eur J Epidemiol. 2012.
- Tiemeier H, Velders FP, et al. The Generation R Study: A review of design, findings to date, and a study of the 5-HTTLPR by environmental interaction from fetal life onward. J Am Acad Child Adolesc Psychiatry. 2012.
Maastricht Study
Study website: www.demaastrichtstudie.nl
Organization website: www.maastrichtuniversity.nl
Study population size: 10000 participants (expected; study started in 2010, imaging started end 2012).
Study population: 5000 with diabetes mellitus type 2, 5000 healthy participants, aged 40-75 years.
Imaging modality 1: ultrasound – Abdominal fat, cardiac
Imaging modality 2: plain radiographs – Knee
Imaging modality 3: DEXA – Body composition
Imaging modality 5: CT – Coronary calcium scoring, Coronary CTA (future plans)
Imaging modality 5: MRI – Brain, body fat quantification, carotids
Key publications: not yet available.
NELSON Study
Nederlands-Leuvens Longkanker Screenings Onderzoek
Study website:www.nelsonproject.nl
Organization website: n.a.
Study population size: 15000 participants, of which 7500 with imaging.
Study population: population with smokers and ex-smokers, aged 50 – 75 years.
Imaging modality 1: CT – Lungs
Key publications:
- Van Iersel CA, de Koning HJ, et al. Risk-based selection from the general population in a screening trial: selection criteria, recruitement and power for the Dutch-Belgian randomised lung cancer multi-slice CT screening trial (NELSON). Int J Cancer. 2007.
- Horeweg N, van der Aalst CM, et al. Volumetric computer tomography screening for lung cancer: three rounds of the NELSON trial. Eur Respir J.2013.
NEO Study
Dutch Epidemiology of Obesity Study
Study website:www.neo-studie.nl or https://www.lumc.nl/con/4060/83010/85843/90302015043229/
Organization website: www.lumc.nl
Study population size: 6000 participants
Study population: population with obesity (BMI > 27 kg/m2), aged 45 – 65 years
Imaging modality 1: MRI – Abdomen, Heart, Brain, Knee
Imaging modality 2: Ultrasound – Carotid-IMT
Key publications: not yet available.
NEO-kids Study
Dutch Epidemiology of Obesity in Children Study
Study website: www.neo-studie.nl
Organization website: www.lumc.nl
Study population size: 300 participants
Study population: children with obesity (referred through outpatient clinic)
Imaging modality 1: MRI – Brain
Key publications (see also: www.neo-studie.nl/default.asp?itemID=214&itemTitle=Publicaties):
- van den Berg L, van Beekum O, et al.Melanocortin-4 receptor gene mutations in a Dutch cohort of obese children. Obesity. 2010.
NESDA Study
Dutch Study on Depression and Anxiety
Study website: www.nesda.nl
Organization website: multicenter study [e.g. : Leiden (www.lumc.nl), Amsterdam (www.vu.nl), Groningen (www.umcg.nl)]
Study population size: 2981 participants
Study population: patients with depression or anxiety disorder and healthy participants
Imaging modality 1: funtional MRI – Brain (subgroup)
Key publications (see also: www.nesda.nl –> publications):
- Penninx BW, Beekman AT, et al. The Netherlands Study of Depression and Anxiety: rationale, objectives and methods. International Journal of Methods in Psychiatric Research. 2008.
- Veer IM, Beckmann CF, et al. Whole brain resting-state analysis reveals decreased functional connectivity in major depression. Frontiers in Systems Neuroscience. 2010.
PROVIDI Study
PROgnostic Value of unrequested Information in Diagnostic Imaging
Key publications:
- Gondrie MJ, Mali WP, et al. The PROgnostic Value of unrequested Information in Diagnostic Imaging (PROVIDI) Study: rationale and design. Eur J Epidemiol. 2010.
Rotterdam Study
The Rotterdam Scan Study – A brain-MRI Study, incorporated in The Rotterdam Study
Study website: www.erasmus-epidemiology.nl/research/ergo.html , www.ergo-onderzoek.nl
Organization website: www.erasmusmc.nl, www.erasmus-epidemiology.nl
Study population size: Rotterdam Study : 14926 participants, Rotterdam Scan Study : 5886 with imaging as of Jan 2011.
Study population: healthy population, aged 45 and older
Imaging modality 1: ultrasound – Carotid-IMT, Transcranial Doppler, Echocardiography, Liver
Imaging modality 2: plain radiographs – hip, knee, hands
Imaging modality 3: DXA – hip
Imaging modality 4: CT – Vascular system, including coronary arteries and carotid arteries
Imaging modality 5: MRI – Brain (Rotterdam Scan Study), carotid arteries, knee
Key publications (see also: www.epib.nl/publications/index.html):
- Hofman A, Grobbee DE, et al. Determinants of disease and disability in the elderly: the Rotterdam Elderly Study. Eur J Epidemiol. 1991.
- Hofman A, Duijn CM, et al. The Rotterdam Study: 2012 objectives and design update. Eur J Epidemiol. 2011.
- Ikram MA, van der Lugt A, et al. The Rotterdam Scan Study: design and update up to 2012. Eur J Epidemiol. 2011.
RUN DMC Study
Radboud University Nijmegen Diffusion tensor and Magnetic resonance imaging Cohort
Study website: n.a.
Organization website: www.ru.nl
Study population size: 503 participants
Study population: participants with cerebral small vessel disease, aged 50 – 85 years
Imaging modality 1: MRI – Brain
Key publications:
- van Norden AGW, de Laat KF et al.Causes and consequences of cerebral small vessel disease. The RUN DMC study: a prospective cohort study. Study rationale and protocol. BMC Neurol. 2011.
- van Norden AGW, de Laat KF et al.Diffusion tensor imaging and cognition in cerebral small vessel disease: The RUN DMC study. Biochimica et Biophysica Acta (BBA) – Molecular Basis of Disease. 2012.
- de Laat KF, Reid AT et al. Cortical thickness is associated with gait disturbances in cerebral small vessel disease. NeuroImage. 2012.
SMART Study
Second Manifestations of ARTerial disease Study / The SMART-MR – A brain-MRI Study, incorporated in The SMART Study
Study website: www.umcutrecht.nl/subsite/Vasculair-Preventie-Programma/Onderzoek/SMART_Study_Group.htm
Organization website: www.umcutrecht.nl
Study population size: 1300 with imaging (SMART-MR)
Study population: population with atherosclerotic disease, aged 18-79 years
Imaging modality 1: MRI – Brain, carotid arteries, knee (only SMART-MR population)
Imaging modality 2: Ultrasound – carotid arteries (in whole SMART – population)
Key publications:
- Geerlings MI, Appelman AP, et al. Brain volumes and cerebrovascular lesions on MRI in patients with atherosclerotic disease. The SMART-MR study. Atherosclerosis. 2010.
- Appelman AP, van der Graaf Y, et al.Total cerebral blood flow, white matter lesions and brain atrophy: the SMART-MR study. JCBFM. 2008.
- Simons PCG, Algra A, et al. Second Manifestations of ARTerial disease (SMART) study: Rationale and design. Eur J Epidemiol. 1999.
