France

3C Study

The Three-City Study

Study website: www.three-city-study.com/the-three-city-study.php
Organization website: www.upmc.fr
Study population size: 9294 participants
Study population: healthy population, aged 65 years and older
Imaging modality 1: ultrasound – Carotid-IMT
Imaging modality 2: MRI – Brain MRI

Key publications:

  • The 3C Study Group. Vascular factors and risk of dementia. Design of the Three-City Study and baseline characteristics of the study population. Neuroepidemiology, 2003.
  • Elbaz A, Ripert M, et al. Common carotid artery intima-media thickness, carotid plaques, and walking speed. Stroke, 2005.
  • Ritchie K, Carrière I, et al. The neuroprotective effect of caffeine: a prospective population study (The Three City Study). Neurology, 2007.
  • Godin O, Dufouil C, et al. White matter lesions as a predictor of depression in the elderly- The 3C-Dijon study. Biological Psychiatry, 2008.
  • Maillard P, Delcroix N, et al. An automated procedure for the assessment of white matter hyperintensities on multispectral (T1, T2, PD) MRI and its between-centre reproducibility evaluation on two large community databases. Neuroradiology, 2008.
  • Debette S, Bis JC, et al. Genome-wide association studies of MRI-defined brain infarcts: meta-analysis from the CHARGE Consortium. Stroke, 2010.
  • Stewart R, Godin O, et al. Longitudinal neuroimaging correlates of subjective memory impairment: 4-year prospective community study. Br J Psychiatry, 2011. 

 

EVA Study

The Epidemiology of Vascular Aging Study

Study website: n.a.
Organization website: n.a.
Study population size: 1389 participants
Study population: healthy population, aged 59 – 71 years old
Imaging modality 1: ultrasound – carotid-IMT
Imaging modality 2: MRI – Brain MRI

Key publications:

  • Bonithon-Kopp C, Touboul PJ, et al. Relation of Intima-Media Thickness to Atherosclerotic Plaques in Carotid Arteries
    The Vascular Aging (EVA) Study. Arterioscler Thromb Vasc Biol, 1996.
  • Dufouil C, Ducimetière P, et al. Sex differences in the association between alcohol consumption and cognitive performance. EVA Study Group. Epidemiology of Vascular Aging. Am J Epidemiol, 1997.
  • Tzourio C, Dufouil C, et al. Cognitive decline in individuals with high blood pressure: a longitudinal study in the elderly. EVA Study Group. Epidemiology of Vascular Aging. Neurology, 1999.
  • Dufouil C, de Kersaint-Gilly A, et al. Longitudinal study of blood pressure and white matter hyperintensities: the EVA MRI Cohort. Neurology, 2001. 
  • Pico F, Dufouil C, et al. Longitudinal study of carotid atherosclerosis and white matter hyperintensities: the EVA-MRI cohort. Cerebrovasc Dis, 2002.